Perivascular epithelioid tumours (PEComas) of Gynaecological Origin

Perivascular epithelioid tumours (PEComas) of Gynaecological Origin

Perivascular epithelioid tumours (PEComas) of Gynaecological Origin (2528)

Antonia Jones ¹

Gynaecology Oncology, Mercy Hospital for Women, Heidelberg, Vic, Australia

PEComas are rare tumours of the gynaecological tract only recognised and described in the last 20 years.

These tumours occur at many sites and are characterised by the presence of an epitheloid cell of mixed myomelanocytic immunophenotype. Whilst the exact cell of origin has not been unequivocally established, embryonal studies suggest a neural-crest stem cell that is capable of myoid and melanocytic differentiation. The tumour family includes previously recognised entities such as angiomyoplioma, clear cell ‘sugar’ tumours of the lung and lymphangioleiomyomatosis. This talk aims to highlight the current knowledge of PEComas of extra-gynaecological tract origin including histology, morphology, immunohistochemistry and genetics and then to summarise all reported cases of gynaecological PEComas to date. It will discuss some of the issues with PEComa prognostic classification and examine the performance of several prognostic classification systems for malignancy in these tumours.

Authors contributing to this abstract.

Jones, A

Antonia Jones completed medical school in 2004, was admitted as a RANZCOG fellow in 2017 and became a certified Gynaecological Oncologist (CGO) in 2021. She remains committed to the care of women with gynaecological cancer, from primary prevention through to surgery and transition into palliative care. She has been a reviewer for several journals (APJCO and ANZJOG), an organising committee member for the 4th Victorian Cancer survivorship conference in 2022, an OCA (Ovarian Cancer Australia) survivorship Resource Advisory Group member, a current examiner for the CGO exam committee and a CGO Curriculum review committee member and an ASCCP Committee member (Australian Society for Colposcopy and Cervical Pathology). She is the surgical oncology lead for the RWH ERAS (Enhanced recovery after surgery) program as well as the Principle Investigator for TUBA-WISP II (TUbectomy with delayed oophorectomy as an alternative to risk-reducing salpingo-oophorectomy in BrcA-Women to assess Safety and Prevention) and Pre-ANVU (Assessment of accuracy of high-resolution groin ultrasound as a non-invasive alternative for identifying vulvar cancer spread to lymph nodes) at Mercy Hospital. She works full time in public practice between Mercy Hospital for Women in Heidelberg and The Royal Women’s Hospital in Parkville and she enjoys research (preferably reading other people’s), eating deep fried carbohydrates and trying to avoid parenting her exhausting children.

Perivascular epithelioid tumours (PEComas) of Gynaecological Origin (2528)

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Jones, A

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