Sentinel node detection in operable cervical cancer - a proposal for a prospective ASGO study — YRD
  1. Schedule
  2. Session 7
  3. Sentinel node detection in operable cervical cancer - a proposal for a prospective ASGO study

Sentinel node detection in operable cervical cancer - a proposal for a prospective ASGO study (2427)

Vivek Arora 1 2 , Archana Rao 3
  1. Gynaecological Oncology, Royal Women's Hospital, Melbourne, VIC, Australia
  2. Western Health, Melbourne, VIC
  3. Gynaecologic Oncology, Royal Hospital for Women, Randwick, NSW, Australia

Lymph node status is considered to be the most important prognostic factor in women diagnosed with cervical cancer. Lymph node positivity is associated with halving of survival, even with post-operative adjuvant treatment.

There is mounting interest in the role of sentinel nodes in cervical cancer. The reasons for increased interest include: possibility of limited nodal excision if validated and hence reduced morbidity; and probability of increased detection of micro metastases and identification of high-risk group who may benefit from adjuvant treatment. Based on the pooled results from the current literature, the sensitivity and the detection rate of sentinel nodes in cervical cancer approaches 90%. However, little is known about the false negative rate with this approach but has reportedly been as high as 10-20%. This is a proposal for a prospective ASGO study.

  1. Holman LL, Levenback CF, Frumovitz M. Sentinel Lymph Node Evaluation in Women with Cervical Cancer. The Journal of Minimally Invasive Gynecology. Elsevier Ltd; 2014 Jul 8;21(4):540–5.
  2. Cormier B, Diaz JP, Shih K, Sampson RM, Sonoda Y, Park KJ, et al. Establishing a sentinel lymph node mapping algorithm for the treatment of early cervical cancer. Gynecologic Oncology. 2011 Aug;122(2):275–80.
  3. Cibula D, Abu-Rustum NR, Dusek L, Zikan M, Zaal A, Sevcik L, et al. Gynecologic Oncology. Gynecologic Oncology. Elsevier Inc; 2012 Mar 1;124(3):496–501.
  4. Kadkhodayan S, Hasanzadeh M, Treglia G, Azad A, Yousefi Z, Zarifmahmoudi L, et al. ScienceDirect. European Journal of Surgical Oncology. Elsevier Ltd; 2015 Jan 1;41(1):1–20.
  5. Hertel H. Cervical Cancer and the Role of Lymph Node Staging Cons Sentinel Concept. International Journal of Gynecological Cancer. 2010 Oct;20:S37–8.