Fallopian tube intra-luminal tumour cells in high grade endometrial carcinoma: associations and outcomes — YRD
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  2. Session 2
  3. Fallopian tube intra-luminal tumour cells in high grade endometrial carcinoma: associations and outcomes

Fallopian tube intra-luminal tumour cells in high grade endometrial carcinoma: associations and outcomes (2639)

Emma R Allanson 1 , Colin Stewart 1 , Heidi Shukralla 1 , Stuart Salfinger 1 2 , Jason Tan 1 2 , Yee Leung 1
  1. King Edward Memorial Hospital, Subiaco, Western Australia
  2. St John of God Hospital, Subiaco

Objective

We aimed to investigate the correlation of intra-luminal tumour cells (ILTCs) with clinicopathological parameters and outcomes in 247 consecutive high-grade endometrial carcinomas.

Results

ILTCs were identified in 66 (27%) cases. There was no relationship with the histological subtype of carcinoma. There was a correlation between ILTC and tumour stage (p<0.001). ILTCs were associated with positive PFC (OR 3.97, 95%CI 2.68-5.89, p<0.001). There was a negative correlation between prior hysteroscopy with curettage and the presence of ILTCs (OR 0.57, 95% CI 0.38-0.86, p=0.016). This relationship persisted when adjusted for tumour stage, subtype, mode of surgery and the experience level of the surgeon (OR 0.51, p=0.038). There was no significant association between the presence of ILTCs and the type of surgery or the experience of the primary surgeon.

Conclusion

Hysteroscopy significantly reduces the likelihood of finding ILTCs. ILTC remains a potential histological consideration in predicting patient outcomes in high-grade endometrial cancer.